STRING 9.05 
  MSH6 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
mutS homolog 6 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resyn [...] (1360 aa)
(Homo sapiens)
Predicted Functional Partners:
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); Component of the post-replicative [...] (934 aa)
proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delt [...] (261 aa)
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form [...] (756 aa)
PMS2 postmeiotic segregation increased 2 (S. cerevisiae); Component of the post-replicative DNA [...] (862 aa)
PMS1 postmeiotic segregation increased 1 (S. cerevisiae); Probably involved in the repair of mi [...] (932 aa)
breast cancer 1, early onset; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellul [...] (1863 aa)
mutY homolog (E. coli); Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to [...] (549 aa)
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
protein kinase, DNA-activated, catalytic polypeptide; Serine/threonine-protein kinase that acts [...] (4127 aa)
replication factor C (activator 1) 4, 37kDa; The elongation of primed DNA templates by DNA poly [...] (363 aa)
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
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