STRING 9.05 
  MSH6 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
MSH6
mutS homolog 6 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resyn [...] (1360 aa)
(Homo sapiens)
Predicted Functional Partners:
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); Component of the post-replicative [...] (934 aa)
  0.999
PCNA
proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delt [...] (261 aa)
     0.999
MLH1
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form [...] (756 aa)
  0.999
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae); Component of the post-replicative DNA [...] (862 aa)
   0.992
PMS1
PMS1 postmeiotic segregation increased 1 (S. cerevisiae); Probably involved in the repair of mi [...] (932 aa)
    0.974
BRCA1
breast cancer 1, early onset; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellul [...] (1863 aa)
     0.968
MUTYH
mutY homolog (E. coli); Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to [...] (549 aa)
      0.966
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
      0.960
PRKDC
protein kinase, DNA-activated, catalytic polypeptide; Serine/threonine-protein kinase that acts [...] (4127 aa)
     0.959
RFC4
replication factor C (activator 1) 4, 37kDa; The elongation of primed DNA templates by DNA poly [...] (363 aa)
      0.949
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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