STRING 9.05 
  TARDBP protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TARDBP
TAR DNA binding protein; DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat (414 aa)
(Homo sapiens)
Predicted Functional Partners:
EXOSC10
exosome component 10; Part of a post-splicing multiprotein complex involved in both mRNA nuclea [...] (885 aa)
      0.999
XRN2
5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote [...] (950 aa)
      0.999
UBC
ubiquitin C (685 aa)
       0.994
ATXN2
ataxin 2 (1313 aa)
      0.961
SOD1
superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells [...] (154 aa)
       0.929
FUS
fused in sarcoma; Binds both single-stranded and double-stranded DNA and promotes ATP-independe [...] (526 aa)
     0.900
SQSTM1
sequestosome 1; Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 [...] (440 aa)
      0.886
VCP
valosin-containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and [...] (806 aa)
      0.862
ACRV1
acrosomal vesicle protein 1 (265 aa)
       0.840
HMOX1
heme oxygenase (decycling) 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge [...] (288 aa)
       0.800
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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