STRING 9.05 
  WNK4 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
WNK4
WNK lysine deficient protein kinase 4; Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis (By similarity) (1243 aa)
(Homo sapiens)
Predicted Functional Partners:
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1; In the kidney, probably plays a m [...] (391 aa)
       0.954
SLC12A3
solute carrier family 12 (sodium/chloride transporters), member 3; Electrically silent transpor [...] (1030 aa)
      0.916
STK39
serine threonine kinase 39 (STE20/SPS1 homolog, yeast); May act as a mediator of stress-activat [...] (545 aa)
     0.901
CLDN7
claudin 7; Plays a major role in tight junction-specific obliteration of the intercellular spac [...] (211 aa)
       0.854
OCLN
occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellul [...] (522 aa)
       0.851
SMAD2
SMAD family member 2; Transcriptional modulator activated by TGF-beta and activin type 1 recept [...] (467 aa)
       0.800
CLDN4
claudin 4; Plays a major role in tight junction-specific obliteration of the intercellular spac [...] (209 aa)
      0.768
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like; E3 ubiquitin-protein li [...] (975 aa)
      0.766
CLDN3
claudin 3; Plays a major role in tight junction-specific obliteration of the intercellular spac [...] (220 aa)
      0.744
SGK1
serum/glucocorticoid regulated kinase 1; Protein kinase that plays an important role in cellula [...] (526 aa)
     0.743
 
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Co-expression Experiments Databases Textmining
 
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