STRING 9.05 
  CCL4 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CCL4
chemokine (C-C motif) ligand 4; Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B (92 aa)
(Homo sapiens)
Predicted Functional Partners:
CCR1
chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP- [...] (355 aa)
    0.994
CCR5
chemokine (C-C motif) receptor 5; Receptor for a number of inflammatory CC-chemokines including [...] (352 aa)
    0.987
CCL3
chemokine (C-C motif) ligand 3; Monokine with inflammatory and chemokinetic properties. Binds t [...] (92 aa)
    0.967
CCR3
chemokine (C-C motif) receptor 3; Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin- [...] (355 aa)
     0.966
CCR8
chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate mon [...] (355 aa)
     0.960
CXCL2
chemokine (C-X-C motif) ligand 2; Produced by activated monocytes and neutrophils and expressed [...] (107 aa)
      0.940
CCR7
chemokine (C-C motif) receptor 7; Receptor for the MIP-3-beta chemokine. Probable mediator of E [...] (378 aa)
     0.938
CXCR3
chemokine (C-X-C motif) receptor 3; Receptor for CXCL9, CXCL10 and CXCL11 and mediates the prol [...] (415 aa)
     0.935
CCR2
chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduce [...] (374 aa)
      0.929
IL1B
interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation [...] (269 aa)
      0.928
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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