STRING 9.05 
  IL6 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
IL6
interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] (212 aa)
(Homo sapiens)
Predicted Functional Partners:
IL6R
interleukin 6 receptor; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, [...] (468 aa)
     0.999
IL6ST
interleukin 6 signal transducer (gp130, oncostatin M receptor); Signal-transducing molecule. Th [...] (918 aa)
     0.999
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor); Transcription [...] (770 aa)
      0.996
SOCS3
suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feed [...] (225 aa)
     0.995
JAK2
Janus kinase 2; Plays a role in leptin signaling and control of body weight (By similarity). Ty [...] (1132 aa)
      0.994
JUN
jun oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'- [...] (331 aa)
      0.994
STAT1
signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of t [...] (750 aa)
      0.994
IL17A
interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. [...] (155 aa)
      0.994
IL1B
interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation [...] (269 aa)
      0.991
IL23R
interleukin 23 receptor; Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL2 [...] (629 aa)
      0.989
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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