STRING 9.05 
  VWF protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
VWF
von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (2813 aa)
(Homo sapiens)
Predicted Functional Partners:
GP1BA
glycoprotein Ib (platelet), alpha polypeptide; GP-Ib, a surface membrane protein of platelets, [...] (640 aa)
      0.999
F8
coagulation factor VIII, procoagulant component; Factor VIII, along with calcium and phospholip [...] (2351 aa)
      0.998
ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif, 13; Cleaves the vWF multimers in plasma [...] (1427 aa)
     0.972
F7
coagulation factor VII (serum prothrombin conversion accelerator); Initiates the extrinsic path [...] (466 aa)
       0.953
VEGFA
vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and [...] (412 aa)
       0.947
SIRPA
signal-regulatory protein alpha; Immunoglobulin-like cell surface receptor for CD47. Acts as do [...] (504 aa)
      0.939
IGLL5
Putative uncharacterized protein IGLV3-21 (237 aa)
      0.938
LOC652493
Ig kappa chain C region (240 aa)
       0.937
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alph [...] (1039 aa)
      0.935
GATA2
GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression [...] (480 aa)
       0.857
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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