STRING 9.05 
  PALB2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PALB2
partner and localizer of BRCA2; Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteosome-mediated degradation (1186 aa)
(Homo sapiens)
Predicted Functional Partners:
BRCA2
breast cancer 2, early onset; Involved in double-strand break repair and/or homologous recombin [...] (3418 aa)
   0.999
BRCA1
breast cancer 1, early onset; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellul [...] (1863 aa)
    0.999
RAD51
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); May participate in a common DNA damage r [...] (339 aa)
      0.985
FANCI
Fanconi anemia, complementation group I; Required for maintenance of chromosomal stability. Inv [...] (1328 aa)
     0.974
FANCD2
Fanconi anemia, complementation group D2; Required for maintenance of chromosomal stability. Pr [...] (1471 aa)
     0.965
BRIP1
BRCA1 interacting protein C-terminal helicase 1; DNA-dependent ATPase and 5' to 3' DNA helicase [...] (1249 aa)
     0.921
MORF4
mortality factor 4; Component of the NuA4 histone acetyltransferase (HAT) complex which is invo [...] (362 aa)
      0.916
RAD51AP1
RAD51 associated protein 1; May participate in a common DNA damage response pathway associated [...] (352 aa)
     0.812
MORF4L2
mortality factor 4 like 2; Component of the NuA4 histone acetyltransferase complex which is inv [...] (288 aa)
       0.791
CHEK2
CHK2 checkpoint homolog (S. pombe); Regulates cell cycle checkpoints and apoptosis in response [...] (586 aa)
       0.752
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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