STRING 9.05 
  TRPV4 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TRPV4
transient receptor potential cation channel, subfamily V, member 4; Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (871 aa)
(Homo sapiens)
Predicted Functional Partners:
CALM1
calmodulin 1 (phosphorylase kinase, delta); Calmodulin mediates the control of a large number o [...] (149 aa)
      0.946
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (536 aa)
      0.936
AQP5
aquaporin 5; Forms a water-specific channel. Implicated in the generation of saliva, tears, and [...] (265 aa)
       0.930
PKD2
polycystic kidney disease 2 (autosomal dominant); Functions as a calcium permeable cation chann [...] (968 aa)
       0.900
CALM3
calmodulin 3 (phosphorylase kinase, delta) (149 aa)
       0.870
CALM2
calmodulin 2 (phosphorylase kinase, delta) (149 aa)
       0.870
UBC
ubiquitin C (685 aa)
       0.853
ITPR3
inositol 1,4,5-triphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a seco [...] (2671 aa)
       0.852
ITCH
itchy E3 ubiquitin protein ligase homolog (mouse); Essential component of a ubiquitin-editing p [...] (862 aa)
       0.845
SGK1
serum/glucocorticoid regulated kinase 1; Protein kinase that plays an important role in cellula [...] (526 aa)
       0.814
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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