STRING 9.05 
  IL1B protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
IL1B
interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (269 aa)
(Homo sapiens)
Predicted Functional Partners:
IL1R1
interleukin 1 receptor, type I; Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and int [...] (569 aa)
     0.999
IL1R2
interleukin 1 receptor, type II; Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and in [...] (398 aa)
    0.999
IL1RAP
interleukin 1 receptor accessory protein; Mediates interleukin-1-dependent activation of NF-kap [...] (570 aa)
     0.997
IL18
interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spl [...] (193 aa)
     0.994
CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Thiol protea [...] (404 aa)
     0.992
IL6
interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is [...] (212 aa)
      0.991
MYD88
myeloid differentiation primary response gene (88); Adapter protein involved in the Toll-like r [...] (309 aa)
     0.990
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotrop [...] (969 aa)
     0.989
IL23A
interleukin 23, alpha subunit p19; Associates with IL12B to form the IL-23 interleukin, an hete [...] (189 aa)
      0.988
JUN
jun oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'- [...] (331 aa)
      0.983
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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