STRING 9.05 
  TP63 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TP63
tumor protein p63; Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of TP53/p53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may [...] (680 aa)
(Homo sapiens)
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
       0.995
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
    0.994
TP73
tumor protein p73; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (636 aa)
     0.945
MDM2
Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle a [...] (497 aa)
      0.888
ITCH
itchy E3 ubiquitin protein ligase homolog (mouse); Essential component of a ubiquitin-editing p [...] (862 aa)
      0.886
EP300
microRNA 1281; Functions as histone acetyltransferase and regulates transcription via chromatin [...] (2414 aa)
      0.867
SMAD2
SMAD family member 2; Transcriptional modulator activated by TGF-beta and activin type 1 recept [...] (467 aa)
      0.855
YAP1
Yes-associated protein 1, 65kDa (504 aa)
       0.845
HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B; Binds single-stranded RNA. Has a high affinity for [...] (332 aa)
      0.807
MFGE8
milk fat globule-EGF factor 8 protein; Specific ligand for the alpha-v/beta-3 and alpha-v/beta- [...] (387 aa)
       0.800
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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