STRING 9.05 
  NBN protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
NBN
nibrin; Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recru [...] (754 aa)
(Homo sapiens)
Predicted Functional Partners:
RAD50
RAD50 homolog (S. cerevisiae); Component of the MRN complex, which plays a central role in doub [...] (1312 aa)
     0.999
MRE11A
MRE11 meiotic recombination 11 homolog A (S. cerevisiae); Component of the MRN complex, which p [...] (708 aa)
    0.999
H2AFX
H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset o [...] (143 aa)
      0.999
MDC1
mediator of DNA-damage checkpoint 1 (2089 aa)
      0.999
NFBD1
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) (2089 aa)
      0.998
ATM
ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signa [...] (3056 aa)
      0.998
BRCA1
breast cancer 1, early onset; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellul [...] (1863 aa)
      0.985
ENSG00000137337
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) (2089 aa)
      0.956
SIRT1
sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); NAD-dependent [...] (747 aa)
      0.935
MDM2
Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle a [...] (497 aa)
      0.918
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (17%)
Permalink