STRING 9.05 
  NBN protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
nibrin; Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recru [...] (754 aa)
(Homo sapiens)
Predicted Functional Partners:
RAD50 homolog (S. cerevisiae); Component of the MRN complex, which plays a central role in doub [...] (1312 aa)
MRE11 meiotic recombination 11 homolog A (S. cerevisiae); Component of the MRN complex, which p [...] (708 aa)
H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset o [...] (143 aa)
mediator of DNA-damage checkpoint 1 (2089 aa)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) (2089 aa)
ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signa [...] (3056 aa)
breast cancer 1, early onset; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellul [...] (1863 aa)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) (2089 aa)
sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); NAD-dependent [...] (747 aa)
Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle a [...] (497 aa)
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