STRING 9.05 
  TP53 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over (393 aa)
(Homo sapiens)
Predicted Functional Partners:
Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle a [...] (497 aa)
cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p5 [...] (164 aa)
ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signa [...] (3056 aa)
breast cancer 1, early onset; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellul [...] (1863 aa)
sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); NAD-dependent [...] (747 aa)
microRNA 1281; Functions as histone acetyltransferase and regulates transcription via chromatin [...] (2414 aa)
K(lysine) acetyltransferase 2B; Functions as a histone acetyltransferase (HAT) to promote trans [...] (832 aa)
Sp1 transcription factor; Transcription factor that can activate or repress transcription in re [...] (785 aa)
ring finger and CHY zinc finger domain containing 1; Mediates E3-dependent ubiquitination and p [...] (261 aa)
Mdm4 p53 binding protein homolog (mouse); Inhibits p53- and p73-mediated cell cycle arrest and [...] (490 aa)
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
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