STRING 9.05 
  AKT1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
AKT1
v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protei [...] (480 aa)
(Homo sapiens)
Predicted Functional Partners:
MDM2
Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle a [...] (497 aa)
     0.999
MTOR
mechanistic target of rapamycin (serine/threonine kinase); Kinase subunit of both mTORC1 and mT [...] (2549 aa)
     0.999
UBC
ubiquitin C (685 aa)
     0.999
PTEN
phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatas [...] (403 aa)
     0.999
GSK3B
glycogen synthase kinase 3 beta; Participates in the Wnt signaling pathway. Implicated in the h [...] (433 aa)
    0.999
TSC2
tuberous sclerosis 2; In complex with TSC1, inhibits the nutrient-mediated or growth factor-sti [...] (1807 aa)
    0.999
FOXO1
forkhead box O1; Transcription factor (655 aa)
     0.999
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone. Has ATPase a [...] (854 aa)
      0.999
TERT
telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the re [...] (1132 aa)
     0.999
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression [...] (198 aa)
     0.998
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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