STRING 9.05 
  PIK3R1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha); Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues (724 aa)
(Homo sapiens)
Predicted Functional Partners:
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide; Phosphorylates PtdIns, PtdIns4P and Pt [...] (1068 aa)
     0.999
IRS1
insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. [...] (1242 aa)
     0.999
PDGFRB
platelet-derived growth factor receptor, beta polypeptide; Receptor that binds specifically to [...] (1106 aa)
     0.999
CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence; Participates in signal transducti [...] (906 aa)
     0.999
GRB2
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)
    0.999
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b; E3 ubiquitin-protein ligase whi [...] (982 aa)
      0.999
CD28
CD28 molecule; Involved in T-cell activation, the induction of cell proliferation and cytokine [...] (220 aa)
     0.999
INSR
insulin receptor; This receptor binds insulin and has a tyrosine-protein kinase activity. Isofo [...] (1382 aa)
     0.999
GAB2
GRB2-associated binding protein 2; Adapter protein which acts downstream of several membrane re [...] (676 aa)
     0.999
IRS2
insulin receptor substrate 2; May mediate the control of various cellular processes by insulin (1338 aa)
     0.999
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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