STRING 9.05 
  CDKN2B protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein (138 aa)
(Homo sapiens)
Predicted Functional Partners:
CDK4
cyclin-dependent kinase 4; Probably involved in the control of the cell cycle (303 aa)
     0.996
SMAD4
SMAD family member 4; Common mediator of signal transduction by TGF-beta (transforming growth f [...] (552 aa)
     0.971
ZBTB17
zinc finger and BTB domain containing 17; May function as a housekeeping DNA-binding protein th [...] (803 aa)
     0.964
CDK6
cyclin-dependent kinase 6; Probably involved in the control of the cell cycle. Interacts with D [...] (326 aa)
      0.963
SP1
Sp1 transcription factor; Transcription factor that can activate or repress transcription in re [...] (785 aa)
     0.961
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p5 [...] (164 aa)
      0.953
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression [...] (198 aa)
      0.953
CCND1
cyclin D1; Essential for the control of the cell cycle at the G1/S (start) transition (295 aa)
      0.948
MYC
v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene t [...] (454 aa)
      0.929
SMAD2
SMAD family member 2; Transcriptional modulator activated by TGF-beta and activin type 1 recept [...] (467 aa)
      0.922
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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