STRING 9.05 
  NOTCH1 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
Notch homolog 1, translocation-associated (Drosophila); Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Inv [...] (2555 aa)
(Homo sapiens)
Predicted Functional Partners:
recombination signal binding protein for immunoglobulin kappa J region; Transcriptional regulat [...] (500 aa)
mastermind-like 1 (Drosophila); Acts as a transcriptional coactivator for NOTCH proteins. Has b [...] (1016 aa)
ubiquitin C (685 aa)
F-box and WD repeat domain containing 7; Substrate recognition component of a SCF (SKP1-CUL1-F- [...] (707 aa)
presenilin 1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease comple [...] (467 aa)
deltex homolog 1 (Drosophila); Regulator of Notch signaling, a signaling pathway involved in ce [...] (620 aa)
numb homolog (Drosophila); Implicated in the control of cell fate decisions during development (651 aa)
hairy/enhancer-of-split related with YRPW motif 1; Downstream effector of Notch signaling which [...] (308 aa)
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; Glycosyltransferase that initiate [...] (379 aa)
microRNA 1825; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a [...] (388 aa)
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Co-expression Experiments Databases Textmining
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