STRING 9.05 
  NOTCH1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
NOTCH1
Notch homolog 1, translocation-associated (Drosophila); Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Inv [...] (2555 aa)
(Homo sapiens)
Predicted Functional Partners:
RBPJ
recombination signal binding protein for immunoglobulin kappa J region; Transcriptional regulat [...] (500 aa)
     0.999
MAML1
mastermind-like 1 (Drosophila); Acts as a transcriptional coactivator for NOTCH proteins. Has b [...] (1016 aa)
     0.999
UBC
ubiquitin C (685 aa)
     0.999
FBXW7
F-box and WD repeat domain containing 7; Substrate recognition component of a SCF (SKP1-CUL1-F- [...] (707 aa)
      0.999
PSEN1
presenilin 1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease comple [...] (467 aa)
     0.999
DTX1
deltex homolog 1 (Drosophila); Regulator of Notch signaling, a signaling pathway involved in ce [...] (620 aa)
     0.999
NUMB
numb homolog (Drosophila); Implicated in the control of cell fate decisions during development (651 aa)
     0.999
HEY1
hairy/enhancer-of-split related with YRPW motif 1; Downstream effector of Notch signaling which [...] (308 aa)
     0.997
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; Glycosyltransferase that initiate [...] (379 aa)
     0.996
POFUT1
microRNA 1825; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a [...] (388 aa)
     0.996
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (21%)
Permalink