STRING 9.05 
  UCHL1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity (223 aa)
(Homo sapiens)
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
     0.998
HSPA8
heat shock 70kDa protein 8; Chaperone. Isoform 2 may function as an endogenous inhibitory regul [...] (646 aa)
      0.968
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1; Protein modifier which can be covale [...] (128 aa)
      0.934
SNCA
synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of [...] (140 aa)
      0.932
KRT4
keratin 4 (594 aa)
       0.925
USP21
ubiquitin specific peptidase 21; Deubiquitinates histone H2A, a specific tag for epigenetic tra [...] (565 aa)
       0.871
LAMP2
lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in p [...] (411 aa)
      0.856
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone. Has ATPase a [...] (854 aa)
      0.850
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
       0.846
APP
amyloid beta (A4) precursor protein; N-APP binds TNFRSF21 triggering caspase activation and deg [...] (770 aa)
      0.691
 
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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