STRING 9.05 
  APP protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
APP
amyloid beta (A4) precursor protein; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) (770 aa)
(Homo sapiens)
Predicted Functional Partners:
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); Adapter protein that fo [...] (708 aa)
     0.999
PSEN1
presenilin 1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease comple [...] (467 aa)
      0.998
ATP6V0A4
ATPase, H+ transporting, lysosomal V0 subunit a4; Part of the proton channel of the V-ATPase th [...] (840 aa)
       0.998
ITM2B
integral membrane protein 2B (266 aa)
     0.994
KAT5
K(lysine) acetyltransferase 5; Catalytic subunit of the NuA4 histone acetyltransferase complex [...] (546 aa)
      0.993
NAE1
NEDD8 activating enzyme E1 subunit 1; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 [...] (534 aa)
    0.989
TGFB1
transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differ [...] (390 aa)
     0.987
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1; Putative function in synaptic [...] (837 aa)
      0.983
BACE1
beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid prec [...] (501 aa)
      0.978
APOE
apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particle [...] (317 aa)
      0.977
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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