STRING 9.05 
  KIT protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K) (976 aa)
(Homo sapiens)
Predicted Functional Partners:
KITLG
KIT ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of bo [...] (273 aa)
     0.999
GRB2
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)
     0.999
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha); Binds to activated (phosphorylated) pr [...] (724 aa)
     0.999
PTPN11
protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cyt [...] (593 aa)
     0.995
PTPN6
protein tyrosine phosphatase, non-receptor type 6; Plays a key role in hematopoiesis. This PTPa [...] (624 aa)
     0.994
JAK2
Janus kinase 2; Plays a role in leptin signaling and control of body weight (By similarity). Ty [...] (1132 aa)
    0.990
CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence; Participates in signal transducti [...] (906 aa)
     0.987
GRB7
growth factor receptor-bound protein 7; Interacts with the cytoplasmic domain of the epidermal [...] (532 aa)
     0.986
TEC
tec protein tyrosine kinase (631 aa)
    0.985
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Down regulates expression of stem cel [...] (512 aa)
    0.984
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (15%)
Permalink