STRING 9.05 
  SPINK1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
SPINK1
serine peptidase inhibitor, Kazal type 1; This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas (79 aa)
(Homo sapiens)
Predicted Functional Partners:
CTRC
chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity (268 aa)
      0.912
TMPRSS15
protease, serine, 7 (enterokinase); Responsible for initiating activation of pancreatic proteol [...] (1019 aa)
      0.891
PRSS3
protease, serine, 3 (304 aa)
       0.889
PRSS1
protease, serine, 2 (trypsin 2); Has activity against the synthetic substrates Boc-Phe- Ser-Arg [...] (247 aa)
       0.841
EGFR
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avi [...] (1210 aa)
       0.828
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member [...] (1480 aa)
       0.750
CTSB
cathepsin B; Thiol protease which is believed to participate in intracellular degradation and t [...] (339 aa)
       0.675
NRSN1
neurensin 1; May play an important role in neural organelle transport, and in transduction of n [...] (195 aa)
      0.634
ELN
elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expa [...] (724 aa)
       0.621
HTRA1
HtrA serine peptidase 1; Protease that regulate the availability of IGFs by cleaving IGF-bindin [...] (480 aa)
       0.567
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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