STRING 9.05 
  ERAP1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
ERAP1
endoplasmic reticulum aminopeptidase 1; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play [...] (948 aa)
(Homo sapiens)
Predicted Functional Partners:
HLA-B
major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens [...] (433 aa)
      0.949
HLA-B57
HLA class I histocompatibility antigen, B-49 alpha chain Precursor (MHC class I antigen B*49)(B [...] (433 aa)
      0.939
Cw
HLA class I histocompatibility antigen, Cw-2 alpha chain Precursor (MHC class I antigen Cw*2); [...] (397 aa)
      0.929
HLA-A
major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens [...] (371 aa)
      0.929
HLC-C
HLA class I histocompatibility antigen, Cw-8 alpha chain Precursor (MHC class I antigen Cw*8); [...] (397 aa)
      0.927
B*15
HLA class I histocompatibility antigen, B-52 alpha chain Precursor (MHC class I antigen B*52)(B [...] (362 aa)
      0.922
CALR
calreticulin; Molecular calcium binding chaperone promoting folding, oligomeric assembly and qu [...] (417 aa)
      0.921
B-3501
HLA class I histocompatibility antigen, B-35 alpha chain Precursor (MHC class I antigen B*35); [...] (433 aa)
      0.914
B2M
beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved [...] (119 aa)
      0.912
HLA-B41
HLA class I histocompatibility antigen, B-8 alpha chain Precursor (MHC class I antigen B*8); In [...] (362 aa)
      0.910
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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