STRING 9.05 
  NPM1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin); Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors TP53/p53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4 (294 aa)
(Homo sapiens)
Predicted Functional Partners:
NCL
nucleolin; Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found as [...] (710 aa)
    0.999
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); Capable of inducing cell c [...] (173 aa)
      0.998
UBC
ubiquitin C (685 aa)
      0.998
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
      0.997
CENPA
centromere protein A; Histone H3-like variant which exclusively replaces conventional H3 in the [...] (140 aa)
    0.992
HJURP
Holliday junction recognition protein; Centromeric protein that plays a central role in the inc [...] (748 aa)
     0.991
NSUN2
NOP2/Sun domain family, member 2; RNA methyltransferase that methylates tRNAs, and possibly RNA [...] (767 aa)
    0.987
SENP3
SUMO1/sentrin/SMT3 specific peptidase 3; Protease that releases SUMO2 and SUMO3 monomers from s [...] (574 aa)
      0.985
CDK2
cyclin-dependent kinase 2; Involved in the control of the cell cycle. Interacts with cyclins A, [...] (298 aa)
      0.981
RPL5
small nucleolar RNA, C/D box 21; Required for rRNA maturation and formation of the 60S ribosoma [...] (297 aa)
      0.962
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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