STRING 9.05 
  TNFRSF11B protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b; Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis (401 aa)
(Homo sapiens)
Predicted Functional Partners:
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11; Cytokine that binds to TNFRSF11B/OPG and [...] (317 aa)
     0.999
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10; Cytokine that binds to TNFRSF10A/TRAILR1 [...] (281 aa)
     0.970
TGFB1
transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differ [...] (390 aa)
       0.884
IL18
interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spl [...] (193 aa)
       0.867
IL17A
interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. [...] (155 aa)
       0.865
PPARG
peroxisome proliferator-activated receptor gamma; Receptor that binds peroxisome proliferators [...] (505 aa)
       0.857
F2
coagulation factor II (thrombin); Thrombin, which cleaves bonds after Arg and Lys, converts fib [...] (622 aa)
      0.851
PRL
prolactin; Prolactin acts primarily on the mammary gland by promoting lactation (227 aa)
       0.830
IGF1R
insulin-like growth factor 1 receptor; This receptor binds insulin-like growth factor 1 (IGF1) [...] (1367 aa)
       0.829
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase); On ligand binding, form [...] (1038 aa)
       0.823
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (32%)
Permalink