STRING 9.05 
  LRRK2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
LRRK2
leucine-rich repeat kinase 2; Probable protein kinase whose role is not yet known. May play a role in the phosphorylation of proteins central to Parkinson disease. May also have GTPase activity (2527 aa)
(Homo sapiens)
Predicted Functional Partners:
SNCA
synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of [...] (140 aa)
      0.981
STUB1
STIP1 homology and U-box containing protein 1; Modulates the activity of several chaperone comp [...] (303 aa)
      0.908
PARK2
Parkinson disease (autosomal recessive, juvenile) 2, parkin; Functions within a multiprotein E3 [...] (465 aa)
      0.899
MSN
moesin; Probably involved in connections of major cytoskeletal structures to the plasma membran [...] (577 aa)
       0.884
DVL1
dishevelled, dsh homolog 1 (Drosophila); May play a role in the signal transduction pathway med [...] (670 aa)
       0.852
MKKS
McKusick-Kaufman syndrome; May play a role in protein processing in limb, cardiac and reproduct [...] (570 aa)
       0.848
HSPA4
heat shock 70kDa protein 4 (840 aa)
       0.844
CDC37
microRNA 1181; Co-chaperone that binds to numerous kinases and promotes their interaction with [...] (378 aa)
       0.844
EIF2C2
Protein argonaute-2 (EC 3.1.26.n1)(Argonaute2)(hAgo2)(Protein slicer)(PAZ Piwi domain protein)( [...] (859 aa)
      0.841
LCA5
Leber congenital amaurosis 5; Might be involved in minus end-directed microtubule transport (697 aa)
       0.810
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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