STRING 9.05 
  RAG1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
RAG1
recombination activating gene 1; During lymphocyte development, the genes encoding immunoglobulins and T-cell receptors are assembled from variable (V), diversity (D), and joining (J) gene segments. This combinatorial process, known as V(D)J recombination, allows the generation of an enormous range of binding specificities from a limited amount of genetic information. The RAG1/RAG2 complex initiates this process by binding to the conserved recombination signal sequences (RSS) and introducing a double-strand break between the RSS and the adjacent coding segment. These breaks are generat [...] (1043 aa)
(Homo sapiens)
Predicted Functional Partners:
RAG2
recombination activating gene 2; During lymphocyte development, the genes encoding immunoglobul [...] (527 aa)
     0.997
KPNA1
karyopherin alpha 1 (importin alpha 5); Functions in nuclear protein import as an adapter prote [...] (538 aa)
      0.953
CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15; Sulfotransferase that t [...] (561 aa)
       0.926
KPNA3
karyopherin alpha 3 (importin alpha 4); Functions in nuclear protein import as an adapter prote [...] (521 aa)
       0.848
HIST2H3PS2
histone cluster 2, H3, pseudogene 2 (136 aa)
       0.833
H3F3A
H3 histone, family 3A; Variant histone H3 which replaces conventional H3 in a wide range of nuc [...] (136 aa)
       0.833
H3F3B
H3 histone, family 3B (H3.3B); Variant histone H3 which replaces conventional H3 in a wide rang [...] (136 aa)
       0.833
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1); Functions in nuclear protein import as an [...] (529 aa)
      0.716
HMGB1
high-mobility group box 1; Binds preferentially single-stranded DNA and unwinds double stranded [...] (215 aa)
      0.693
HMGB2
high-mobility group box 2; Binds preferentially single-stranded DNA and unwinds double stranded [...] (209 aa)
      0.651
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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