STRING 9.05 
  PITX2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PITX2
paired-like homeodomain 2; May play an important role in development and maintenance of anterior structures. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity) (324 aa)
(Homo sapiens)
Predicted Functional Partners:
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa; Involved in the regulation of cell adhesi [...] (781 aa)
     0.995
CCND2
cyclin D2; Essential for the control of the cell cycle at the G1/S (start) transition (289 aa)
      0.986
LEF1
lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transc [...] (399 aa)
     0.972
HDAC1
histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (482 aa)
     0.964
FOXC1
forkhead box C1; Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of th [...] (553 aa)
       0.955
LGR4
leucine-rich repeat-containing G protein-coupled receptor 4; Orphan receptor (951 aa)
       0.916
WNT11
wingless-type MMTV integration site family, member 11; Ligand for members of the frizzled famil [...] (354 aa)
       0.865
NOG
noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogene [...] (232 aa)
       0.864
WNT3A
wingless-type MMTV integration site family, member 3A; Ligand for members of the frizzled famil [...] (352 aa)
       0.859
AXIN1
axin 1; Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin [...] (862 aa)
       0.852
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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