STRING 9.05 
  IL8 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
IL8
interleukin 8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively (99 aa)
(Homo sapiens)
Predicted Functional Partners:
CXCR2
chemokine (C-X-C motif) receptor 2; Receptor for interleukin-8 which is a powerful neutrophil c [...] (360 aa)
     0.999
CXCR1
chemokine (C-X-C motif) receptor 1; Receptor to interleukin-8, which is a powerful neutrophils [...] (350 aa)
     0.999
RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic trans [...] (551 aa)
     0.993
JUN
jun oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'- [...] (331 aa)
     0.992
FOS
FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but [...] (380 aa)
      0.989
EGFR
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avi [...] (1210 aa)
      0.989
DARC
Duffy blood group, chemokine receptor; Non-specific receptor for many chemokines such as IL-8, [...] (338 aa)
      0.981
IL1B
interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation [...] (269 aa)
      0.975
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); May play [...] (707 aa)
      0.971
DIF
Tumor necrosis factor Precursor (TNF-alpha)(Tumor necrosis factor ligand superfamily member 2)( [...] (233 aa)
       0.969
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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