STRING 9.05 
  RAG2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
RAG2
recombination activating gene 2; During lymphocyte development, the genes encoding immunoglobulins and T-cell receptors are assembled from variable (V), diversity (D), and joining (J) gene segments. This combinatorial process, known as V(D)J recombination, allows the generation of an enormous range of binding specificities from a limited amount of genetic information. The RAG1/RAG2 complex initiates this process by binding to the conserved recombination signal sequences (RSS) and introducing a double-strand break between the RSS and the adjacent coding segment. These breaks are generat [...] (527 aa)
(Homo sapiens)
Predicted Functional Partners:
RAG1
recombination activating gene 1; During lymphocyte development, the genes encoding immunoglobul [...] (1043 aa)
     0.997
PAX5
paired box 5; May play an important role in B-cell differentiation as well as neural developmen [...] (391 aa)
      0.958
LEF1
lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transc [...] (399 aa)
      0.916
MYB
v-myb myeloblastosis viral oncogene homolog (avian); Transcriptional activator; DNA-binding pro [...] (761 aa)
      0.913
PRKDC
protein kinase, DNA-activated, catalytic polypeptide; Serine/threonine-protein kinase that acts [...] (4127 aa)
       0.906
HIST2H3PS2
histone cluster 2, H3, pseudogene 2 (136 aa)
       0.865
H3F3A
H3 histone, family 3A; Variant histone H3 which replaces conventional H3 in a wide range of nuc [...] (136 aa)
       0.865
H3F3B
H3 histone, family 3B (H3.3B); Variant histone H3 which replaces conventional H3 in a wide rang [...] (136 aa)
       0.865
CD4
CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regul [...] (458 aa)
       0.784
SKP2
S-phase kinase-associated protein 2 (p45); Substrate recognition component of a SCF (SKP1-CUL1- [...] (424 aa)
      0.769
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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