STRING 9.05 
  CYLD protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CYLD
cylindromatosis (turban tumor syndrome); Negative regulator of TRAF2 and NF-kappa-B signaling pathway. Has deubiquitinating activity that is directed towards non-'Lys-48'-linked polyubiquitin chains. The inhibition of NF- kappa-B activation is mediated at least in part, by the deubiquitination and inactivation of TRAF2 and, to a lesser extent, TRAF6 (956 aa)
(Homo sapiens)
Predicted Functional Partners:
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit [...] (487 aa)
     0.999
TRAF6
TNF receptor-associated factor 6; Adapter protein and signal transducer that links members of t [...] (522 aa)
     0.997
UBC
ubiquitin C (685 aa)
     0.995
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; Involved in innate immune defense against viruses. U [...] (925 aa)
     0.993
RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF si [...] (671 aa)
     0.991
TRAF2
TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of t [...] (501 aa)
     0.986
SQSTM1
sequestosome 1; Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 [...] (440 aa)
     0.972
TRAIP
TRAF interacting protein; Inhibits activation of NF-kappa-B mediated by TNF (By similarity) (469 aa)
      0.959
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)
      0.949
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1; Protein modifier which can be covale [...] (128 aa)
      0.939
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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