STRING 9.05 
  C10orf2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
C10orf2
Twinkle protein, mitochondrial Precursor (EC 3.6.1.-)(T7 gp4-like protein with intramitochondrial nucleoid localization)(T7-like mitochondrial DNA helicase)(Progressive external ophthalmoplegia 1 protein); Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a [...] (684 aa)
(Homo sapiens)
Predicted Functional Partners:
KLHL1
kelch-like 1 (Drosophila); May play a role in organizing the actin cytoskeleton of the brain ce [...] (748 aa)
       0.955
POLG
polymerase (DNA directed), gamma; Involved in the replication of mitochondrial DNA (1239 aa)
       0.853
STAMBP
STAM binding protein; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiqu [...] (424 aa)
       0.846
USP8
ubiquitin specific peptidase 8; Hydrolase that can remove conjugated ubiquitin from proteins an [...] (1118 aa)
       0.839
TAC1
tachykinin, precursor 1; Tachykinins are active peptides which excite neurons, evoke behavioral [...] (129 aa)
       0.800
SLC25A4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4; Ca [...] (298 aa)
       0.778
TTPA
tocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between s [...] (278 aa)
       0.778
POLG2
polymerase (DNA directed), gamma 2, accessory subunit; Mitochondrial polymerase processivity su [...] (485 aa)
       0.750
FAM178A
family with sequence similarity 178, member A (1186 aa)
       0.724
ATXN3
ataxin 3; Interacts with key regulators (CBP, p300 and PCAF) of transcription and represses tra [...] (361 aa)
       0.675
 
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Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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