STRING 9.05 
  ADAM17 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
ADAM metallopeptidase domain 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity) (824 aa)
(Homo sapiens)
Predicted Functional Partners:
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avi [...] (1210 aa)
epidermal growth factor (beta-urogastrone); EGF stimulates the growth of various epidermal and [...] (1207 aa)
heparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular prolife [...] (208 aa)
TIMP metallopeptidase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and [...] (211 aa)
Notch homolog 1, translocation-associated (Drosophila); Functions as a receptor for membrane-bo [...] (2555 aa)
MAD2 mitotic arrest deficient-like 1 (yeast); Component of the spindle-assembly checkpoint that [...] (205 aa)
tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/T [...] (461 aa)
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene [...] (1255 aa)
presenilin enhancer 2 homolog (C. elegans); Essential subunit of the gamma-secretase complex, a [...] (101 aa)
ADAM metallopeptidase domain 12; Involved in skeletal muscle regeneration, specifically at the [...] (909 aa)
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