STRING 9.05 
  LEP protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass (167 aa)
(Homo sapiens)
Predicted Functional Partners:
leptin receptor; Receptor for obesity factor (leptin). On ligand binding, mediates signaling th [...] (1165 aa)
signal transducer and activator of transcription 3 (acute-phase response factor); Transcription [...] (770 aa)
glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity [...] (180 aa)
suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feed [...] (225 aa)
Janus kinase 2; Plays a role in leptin signaling and control of body weight (By similarity). Ty [...] (1132 aa)
protein tyrosine phosphatase, non-receptor type 1; May play an important role in CKII- and p60c [...] (435 aa)
ghrelin/obestatin prepropeptide; Ghrelin is the ligand for growth hormone secretagogue receptor [...] (117 aa)
transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differ [...] (390 aa)
C-reactive protein, pentraxin-related; Displays several functions associated with host defense- [...] (224 aa)
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (200 aa)
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
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