STRING 9.05 
  LEP protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
LEP
leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass (167 aa)
(Homo sapiens)
Predicted Functional Partners:
LEPR
leptin receptor; Receptor for obesity factor (leptin). On ligand binding, mediates signaling th [...] (1165 aa)
     0.999
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor); Transcription [...] (770 aa)
     0.997
GCG
glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity [...] (180 aa)
      0.995
SOCS3
suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feed [...] (225 aa)
      0.994
JAK2
Janus kinase 2; Plays a role in leptin signaling and control of body weight (By similarity). Ty [...] (1132 aa)
      0.992
PTPN1
protein tyrosine phosphatase, non-receptor type 1; May play an important role in CKII- and p60c [...] (435 aa)
      0.991
GHRL
ghrelin/obestatin prepropeptide; Ghrelin is the ligand for growth hormone secretagogue receptor [...] (117 aa)
      0.988
TGFB1
transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differ [...] (390 aa)
      0.987
CRP
C-reactive protein, pentraxin-related; Displays several functions associated with host defense- [...] (224 aa)
      0.981
INS
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (200 aa)
       0.980
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (13%)
Permalink