STRING 9.05 
  PRF1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PRF1
perforin 1 (pore forming protein); In the presence of calcium, binds to target cell membranes. Inserts into target cell membranes and forms pores, and so contributes to cytolysis and apoptosis of target cells (555 aa)
(Homo sapiens)
Predicted Functional Partners:
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is ne [...] (247 aa)
    0.999
IL2
interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this prot [...] (153 aa)
      0.994
IL2RA
interleukin 2 receptor, alpha; Receptor for interleukin-2 (272 aa)
      0.991
CD8A
CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing t [...] (235 aa)
     0.979
CD247
CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal t [...] (164 aa)
     0.964
CD3E
CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction (207 aa)
     0.958
IL2RB
interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in rece [...] (551 aa)
     0.957
EOMES
eomesodermin homolog (Xenopus laevis); Functions as a transcriptional activator playing a cruci [...] (686 aa)
     0.955
CD86
CD86 molecule; Receptor involved in the costimulatory signal essential for T-lymphocyte prolife [...] (329 aa)
      0.953
CD3D
CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction (171 aa)
     0.945
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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