STRING 9.05 
  WT1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
WT1
Wilms tumor 1; Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific- isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affi [...] (517 aa)
(Homo sapiens)
Predicted Functional Partners:
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
      0.984
PAWR
PRKC, apoptosis, WT1, regulator; Pro-apoptopic protein capable of selectively inducing apoptosi [...] (340 aa)
      0.968
PAX2
paired box 2; Probable transcription factor that may have a role in kidney cell differentiation [...] (396 aa)
      0.966
WTAP
Wilms tumor 1 associated protein; Regulates G2/M cell-cycle transition by binding to the 3' UTR [...] (396 aa)
      0.962
WTIP
Wilms tumor 1 interacting protein; May monitor slit diaphragm protein assembly, a specialized a [...] (654 aa)
      0.941
TP73
tumor protein p73; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (636 aa)
      0.936
NR0B1
nuclear receptor subfamily 0, group B, member 1; Orphan nuclear receptor. Component of a cascad [...] (470 aa)
       0.927
TERT
telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the re [...] (1132 aa)
      0.926
FHL2
four and a half LIM domains 2; May function as a molecular transmitter linking various signalin [...] (279 aa)
      0.924
SRY
sex determining region Y; Transcriptional regulator which control a genetic switch in male deve [...] (204 aa)
       0.915
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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