STRING 9.05 
  PRKCD protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PRKCD
protein kinase C, delta; This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (676 aa)
(Homo sapiens)
Predicted Functional Partners:
FYN
FYN oncogene related to SRC, FGR, YES; Implicated in the control of cell growth. Plays a role i [...] (537 aa)
    0.994
IRS1
insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. [...] (1242 aa)
      0.993
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor); Transcription [...] (770 aa)
     0.985
STAT1
signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of t [...] (750 aa)
     0.985
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (536 aa)
    0.984
SHC1
SHC (Src homology 2 domain containing) transforming protein 1; Signaling adapter that couples a [...] (584 aa)
     0.981
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide; Phosphorylates PtdIns, PtdIns4P and Pt [...] (1068 aa)
     0.966
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Down regulates expression of stem cel [...] (512 aa)
    0.964
PTK2B
PTK2B protein tyrosine kinase 2 beta; Involved in calcium induced regulation of ion channel and [...] (1009 aa)
   0.962
MAPK3
mitogen-activated protein kinase 3; Involved in both the initiation and regulation of meiosis, [...] (379 aa)
    0.960
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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