STRING 9.05 
  SNCA protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule- associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation (140 aa)
(Homo sapiens)
Predicted Functional Partners:
synuclein, alpha interacting protein (919 aa)
ubiquitin C (685 aa)
Parkinson disease (autosomal recessive, juvenile) 2, parkin; Functions within a multiprotein E3 [...] (465 aa)
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. [...] (620 aa)
STIP1 homology and U-box containing protein 1; Modulates the activity of several chaperone comp [...] (303 aa)
FYN oncogene related to SRC, FGR, YES; Implicated in the control of cell growth. Plays a role i [...] (537 aa)
G protein-coupled receptor kinase 5; Specifically phosphorylates the activated forms of G prote [...] (590 aa)
BCL2-associated agonist of cell death; Promotes cell death. Successfully competes for the bindi [...] (168 aa)
Parkinson disease (autosomal recessive, early onset) 7; Acts as a positive regulator of androge [...] (189 aa)
leucine-rich repeat kinase 2; Probable protein kinase whose role is not yet known. May play a r [...] (2527 aa)
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
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