STRING 9.05 
  SNCA protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
SNCA
synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule- associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation (140 aa)
(Homo sapiens)
Predicted Functional Partners:
SNCAIP
synuclein, alpha interacting protein (919 aa)
     0.999
UBC
ubiquitin C (685 aa)
      0.999
PARK2
Parkinson disease (autosomal recessive, juvenile) 2, parkin; Functions within a multiprotein E3 [...] (465 aa)
     0.998
SLC6A3
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. [...] (620 aa)
     0.989
STUB1
STIP1 homology and U-box containing protein 1; Modulates the activity of several chaperone comp [...] (303 aa)
     0.986
FYN
FYN oncogene related to SRC, FGR, YES; Implicated in the control of cell growth. Plays a role i [...] (537 aa)
     0.983
GRK5
G protein-coupled receptor kinase 5; Specifically phosphorylates the activated forms of G prote [...] (590 aa)
     0.983
BAD
BCL2-associated agonist of cell death; Promotes cell death. Successfully competes for the bindi [...] (168 aa)
      0.983
PARK7
Parkinson disease (autosomal recessive, early onset) 7; Acts as a positive regulator of androge [...] (189 aa)
     0.983
LRRK2
leucine-rich repeat kinase 2; Probable protein kinase whose role is not yet known. May play a r [...] (2527 aa)
      0.981
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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