STRING 9.05 
  PARK7 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PARK7
Parkinson disease (autosomal recessive, early onset) 7; Acts as a positive regulator of androgen receptor- dependent transcription. May function as a redox-sensitive chaperone and as a sensor for oxidative stress. Prevents aggregation of SNCA. Protects neurons against oxidative stress and cell death. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity (189 aa)
(Homo sapiens)
Predicted Functional Partners:
SNCA
synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of [...] (140 aa)
     0.983
AR
androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that re [...] (920 aa)
      0.939
PARK2
Parkinson disease (autosomal recessive, juvenile) 2, parkin; Functions within a multiprotein E3 [...] (465 aa)
      0.936
SOD1
superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells [...] (154 aa)
     0.923
PIAS2
protein inhibitor of activated STAT, 2; Functions as an E3-type small ubiquitin-like modifier ( [...] (621 aa)
      0.896
SOD2
superoxide dismutase 2, mitochondrial; Destroys radicals which are normally produced within the [...] (222 aa)
     0.872
PTEN
phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatas [...] (403 aa)
       0.864
MTA1
metastasis associated 1; May be involved in the regulation of gene expression by covalent modif [...] (715 aa)
       0.846
AKT1
v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylatin [...] (480 aa)
       0.845
MAP3K5
mitogen-activated protein kinase kinase kinase 5; Component of a protein kinase signal transduc [...] (1374 aa)
       0.842
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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