STRING 9.05 
  SMPD1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity (631 aa)
(Homo sapiens)
Predicted Functional Partners:
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1; Hydrolyzes the sphingolipid ceramide into [...] (411 aa)
    0.981
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)
     0.969
SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase); Converts sphing [...] (423 aa)
      0.947
GBA
glucosidase, beta; acid (includes glucosylceramidase) (536 aa)
     0.946
UGCG
UDP-glucose ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphing [...] (394 aa)
      0.942
ASAH2
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2; Hydrolyzes the sphingolipid cera [...] (780 aa)
      0.938
CERK
ceramide kinase; Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phos [...] (537 aa)
      0.933
FASLG
Fas ligand (TNF superfamily, member 6); Cytokine that binds to TNFRSF6/FAS, a receptor that tra [...] (281 aa)
      0.933
FADD
Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 o [...] (208 aa)
      0.932
GALC
galactosylceramidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsph [...] (685 aa)
      0.931
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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