STRING 9.05 
  MAPT protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
MAPT
microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabil [...] (776 aa)
(Homo sapiens)
Predicted Functional Partners:
STUB1
STIP1 homology and U-box containing protein 1; Modulates the activity of several chaperone comp [...] (303 aa)
      0.998
GSK3B
glycogen synthase kinase 3 beta; Participates in the Wnt signaling pathway. Implicated in the h [...] (433 aa)
      0.997
CDK5
cyclin-dependent kinase 5; Probably involved in the control of the cell cycle. Interacts with D [...] (292 aa)
      0.996
UBC
ubiquitin C (685 aa)
      0.996
FYN
FYN oncogene related to SRC, FGR, YES; Implicated in the control of cell growth. Plays a role i [...] (537 aa)
      0.983
APOE
apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particle [...] (317 aa)
      0.978
AKT1
v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylatin [...] (480 aa)
      0.950
SNCA
synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of [...] (140 aa)
      0.943
HSPA4
heat shock 70kDa protein 4 (840 aa)
      0.942
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Adapt [...] (245 aa)
      0.943
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (29%)
Permalink