STRING 9.05 
  POU1F1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
POU1F1
POU class 1 homeobox 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'- TAAAT-3' (317 aa)
(Homo sapiens)
Predicted Functional Partners:
PRL
prolactin; Prolactin acts primarily on the mammary gland by promoting lactation (227 aa)
      0.992
GATA2
GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression [...] (480 aa)
      0.974
CREBBP
CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation [...] (2442 aa)
      0.927
TSHB
thyroid stimulating hormone, beta; Indispensable for the control of thyroid structure and metab [...] (138 aa)
       0.910
NCOR1
nuclear receptor co-repressor 1; Mediates transcriptional repression by certain nuclear recepto [...] (2440 aa)
      0.882
HESX1
HESX homeobox 1; Required for the normal development of the forebrain, eyes and other anterior [...] (185 aa)
       0.782
LHX4
LIM homeobox 4; May play a critical role in the development of respiratory control mechanisms a [...] (390 aa)
       0.752
PITX1
paired-like homeodomain 1; May play a role in the development of anterior structures, and in pa [...] (314 aa)
      0.746
TRH
thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anter [...] (242 aa)
       0.675
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); Transcription factor (485 aa)
      0.662
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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