STRING 9.05 
  ATR protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
ATR
ataxia telangiectasia and Rad3 related; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damag [...] (2644 aa)
(Homo sapiens)
Predicted Functional Partners:
ATRIP
ATR interacting protein; Required for checkpoint signaling after DNA damage. Required for ATR e [...] (791 aa)
      0.999
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
     0.999
CHEK1
CHK1 checkpoint homolog (S. pombe); Required for checkpoint mediated cell cycle arrest in respo [...] (476 aa)
     0.999
BRCA1
breast cancer 1, early onset; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellul [...] (1863 aa)
      0.994
CHEK2
CHK2 checkpoint homolog (S. pombe); Regulates cell cycle checkpoints and apoptosis in response [...] (586 aa)
     0.990
RAD17
RAD17 homolog (S. pombe); Essential for sustained cell growth, maintenance of chromosomal stabi [...] (681 aa)
     0.972
H2AFX
H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset o [...] (143 aa)
      0.969
WRN
Werner syndrome, RecQ helicase-like; Essential for the formation of DNA replication focal cente [...] (1432 aa)
     0.958
TELO2
TEL2, telomere maintenance 2, homolog (S. cerevisiae); May be involved in telomere length regul [...] (837 aa)
      0.924
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); Component of the post-replicative [...] (934 aa)
     0.919
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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