STRING 9.05 
  ESR2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
ESR2
estrogen receptor 2 (ER beta); Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temp [...] (530 aa)
(Homo sapiens)
Predicted Functional Partners:
NCOA3
nuclear receptor coactivator 3; Nuclear receptor coactivator that directly binds nuclear recept [...] (1424 aa)
     0.999
NCOA1
nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear recept [...] (1441 aa)
     0.999
NCOA2
nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear r [...] (1464 aa)
     0.999
ESR1
estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are inv [...] (595 aa)
    0.998
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (536 aa)
      0.983
DDX54
DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the tra [...] (882 aa)
     0.974
NR0B1
nuclear receptor subfamily 0, group B, member 1; Orphan nuclear receptor. Component of a cascad [...] (470 aa)
     0.969
NR0B2
nuclear receptor subfamily 0, group B, member 2; Acts as a negative regulator of receptor-depen [...] (257 aa)
    0.964
PPARG
peroxisome proliferator-activated receptor gamma; Receptor that binds peroxisome proliferators [...] (505 aa)
    0.963
RXRA
retinoid X receptor, alpha; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (462 aa)
    0.961
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (16%)
Permalink