STRING 9.05 
  PDPK1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PDPK1
3-phosphoinositide dependent protein kinase-1; Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive (556 aa)
(Homo sapiens)
Predicted Functional Partners:
AKT1
v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylatin [...] (480 aa)
   0.998
SGK1
serum/glucocorticoid regulated kinase 1; Protein kinase that plays an important role in cellula [...] (526 aa)
   0.998
PRKCZ
protein kinase C, zeta; This is a calcium-independent, phospholipid-dependent, serine- and thre [...] (592 aa)
     0.990
RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1; Phosphorylates specifically ribosomal protei [...] (525 aa)
   0.974
PKN2
protein kinase N2; Exhibits a preference for highly basic protein substrates (By similarity) (984 aa)
     0.950
PKN1
protein kinase N1; Can phosphorylate ribosomal protein S6. Mediates GTPase Rho dependent intrac [...] (948 aa)
     0.949
AKT2
v-akt murine thymoma viral oncogene homolog 2; General protein kinase capable of phosphorylatin [...] (481 aa)
   0.937
PRKCE
protein kinase C, epsilon; This is calcium-independent, phospholipid-dependent, serine- and thr [...] (737 aa)
     0.937
AKT3
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); IGF-1 leads to the act [...] (479 aa)
   0.931
RPS6KB2
ribosomal protein S6 kinase, 70kDa, polypeptide 2; Phosphorylates specifically ribosomal protei [...] (482 aa)
   0.927
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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