STRING 9.05 
  SERPINA1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin (418 aa)
(Homo sapiens)
Predicted Functional Partners:
ELANE
elastase, neutrophil expressed; Modifies the functions of natural killer cells, monocytes and g [...] (267 aa)
      0.991
TGFB1
transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differ [...] (390 aa)
      0.981
A2M
alpha-2-macroglobulin; Is able to inhibit all four classes of proteinases by a unique 'trapping [...] (1474 aa)
      0.973
KLK3
kallikrein-related peptidase 3; Hydrolyzes semenogelin-1 thus leading to the liquefaction of th [...] (261 aa)
      0.972
MIS12
MIS12, MIND kinetochore complex component, homolog (S. pombe); Part of the MIS12 complex which [...] (205 aa)
       0.962
ALB
albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2 [...] (609 aa)
     0.951
PLG
plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a [...] (810 aa)
      0.928
FN1
fibronectin 1; Fibronectins bind cell surfaces and various compounds including collagen, fibrin [...] (2477 aa)
      0.922
TIMP1
TIMP metallopeptidase inhibitor 1; Complexes with metalloproteinases (such as collagenases) and [...] (207 aa)
      0.918
KNG1
kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an impor [...] (644 aa)
      0.918
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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