STRING 9.05 
  GM2A protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
GM2A
GM2 ganglioside activator; Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (193 aa)
(Homo sapiens)
Predicted Functional Partners:
HEXA
hexosaminidase A (alpha polypeptide); Responsible for the degradation of GM2 gangliosides, and [...] (529 aa)
     0.995
HEXB
hexosaminidase B (beta polypeptide); Responsible for the degradation of GM2 gangliosides, and a [...] (556 aa)
     0.988
GLB1
galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glyc [...] (677 aa)
      0.909
ETFA
electron-transfer-flavoprotein, alpha polypeptide; The electron transfer flavoprotein serves as [...] (333 aa)
       0.861
PLD2
phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis [...] (933 aa)
      0.687
BIN3
bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localiz [...] (253 aa)
       0.675
GPLD1
glycosylphosphatidylinositol specific phospholipase D1; This protein hydrolyzes the inositol ph [...] (840 aa)
       0.621
PSAP
prosaposin; The lysosomal degradation of sphingolipids takes place by the sequential action of [...] (524 aa)
      0.597
HMGB3
high-mobility group box 3; Binds preferentially single-stranded DNA and unwinds double stranded [...] (200 aa)
       0.585
SKAP2
src kinase associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion proce [...] (359 aa)
       0.466
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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