STRING 9.05 
  BRCA1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
BRCA1
breast cancer 1, early onset; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage [...] (1863 aa)
(Homo sapiens)
Predicted Functional Partners:
ATM
ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signa [...] (3056 aa)
     0.999
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
     0.999
BRCA2
breast cancer 2, early onset; Involved in double-strand break repair and/or homologous recombin [...] (3418 aa)
    0.999
ESR1
estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are inv [...] (595 aa)
     0.999
UIMC1
ubiquitin interaction motif containing 1; Ubiquitin-binding protein that specifically recognize [...] (719 aa)
     0.999
BARD1
BRCA1 associated RING domain 1; The BRCA1-BARD1 heterodimer coordinates a diverse range of cell [...] (777 aa)
   0.999
RBBP8
retinoblastoma binding protein 8; May modulate the functions ascribed to BRCA1 in transcription [...] (897 aa)
    0.999
RAD51
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); May participate in a common DNA damage r [...] (339 aa)
    0.999
BRIP1
BRCA1 interacting protein C-terminal helicase 1; DNA-dependent ATPase and 5' to 3' DNA helicase [...] (1249 aa)
     0.999
H2AFX
H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset o [...] (143 aa)
     0.999
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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