STRING 9.05 
  NR3C2 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
nuclear receptor subfamily 3, group C, member 2; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (984 aa)
(Homo sapiens)
Predicted Functional Partners:
tripartite motif-containing 24; Interacts selectively in vitro with the AF2-activating domain o [...] (1050 aa)
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), m [...] (491 aa)
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with bro [...] (317 aa)
hydroxysteroid (11-beta) dehydrogenase 2; Catalyzes the conversion of cortisol to the inactive [...] (405 aa)
renin; Renin is a highly specific endopeptidase, whose only known function is to generate angio [...] (406 aa)
heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone. Has ATPase a [...] (854 aa)
FK506 binding protein 4, 59kDa; Component of unactivated mammalian steroid receptor complexes t [...] (459 aa)
heat shock 70kDa protein 4 (840 aa)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); Receptor for glucoco [...] (778 aa)
cytochrome P450, family 11, subfamily B, polypeptide 2; Preferentially catalyzes the conversion [...] (503 aa)
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
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