STRING 9.05 
  NR3C2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
NR3C2
nuclear receptor subfamily 3, group C, member 2; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (984 aa)
(Homo sapiens)
Predicted Functional Partners:
TRIM24
tripartite motif-containing 24; Interacts selectively in vitro with the AF2-activating domain o [...] (1050 aa)
      0.878
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), m [...] (491 aa)
       0.811
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with bro [...] (317 aa)
       0.752
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2; Catalyzes the conversion of cortisol to the inactive [...] (405 aa)
       0.752
REN
renin; Renin is a highly specific endopeptidase, whose only known function is to generate angio [...] (406 aa)
       0.752
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone. Has ATPase a [...] (854 aa)
      0.729
FKBP4
FK506 binding protein 4, 59kDa; Component of unactivated mammalian steroid receptor complexes t [...] (459 aa)
      0.676
HSPA4
heat shock 70kDa protein 4 (840 aa)
      0.661
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); Receptor for glucoco [...] (778 aa)
     0.654
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2; Preferentially catalyzes the conversion [...] (503 aa)
       0.651
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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