STRING 9.05 
  RUNX2 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
RUNX2
runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation (589 aa)
(Homo sapiens)
Predicted Functional Partners:
SMAD3
SMAD family member 3; Transcriptional modulator activated by TGF-beta (transforming growth fact [...] (425 aa)
      0.989
SMAD4
SMAD family member 4; Common mediator of signal transduction by TGF-beta (transforming growth f [...] (552 aa)
      0.987
SOX9
SRY (sex determining region Y)-box 9; Plays an important role in the normal skeletal developmen [...] (509 aa)
      0.978
EP300
microRNA 1281; Functions as histone acetyltransferase and regulates transcription via chromatin [...] (2414 aa)
      0.979
CBFB
core-binding factor, beta subunit; CBF binds to the core site, 5'-PYGPYGGT-3', of a number of e [...] (187 aa)
      0.978
MSX2
msh homeobox 2; Probable morphogenetic role. May play a role in limb- pattern formation. In ost [...] (267 aa)
      0.978
UBC
ubiquitin C (685 aa)
      0.977
BGLAP
bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds [...] (100 aa)
      0.977
RB1
retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Ac [...] (928 aa)
     0.973
SP7
Sp7 transcription factor; Transcriptional activator essential for osteoblast differentiation. B [...] (431 aa)
       0.970
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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