STRING 9.05 
  RUNX2 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation (589 aa)
(Homo sapiens)
Predicted Functional Partners:
SMAD family member 3; Transcriptional modulator activated by TGF-beta (transforming growth fact [...] (425 aa)
SMAD family member 4; Common mediator of signal transduction by TGF-beta (transforming growth f [...] (552 aa)
SRY (sex determining region Y)-box 9; Plays an important role in the normal skeletal developmen [...] (509 aa)
microRNA 1281; Functions as histone acetyltransferase and regulates transcription via chromatin [...] (2414 aa)
core-binding factor, beta subunit; CBF binds to the core site, 5'-PYGPYGGT-3', of a number of e [...] (187 aa)
msh homeobox 2; Probable morphogenetic role. May play a role in limb- pattern formation. In ost [...] (267 aa)
ubiquitin C (685 aa)
bone gamma-carboxyglutamate (gla) protein; Constitutes 1-2% of the total bone protein. It binds [...] (100 aa)
retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Ac [...] (928 aa)
Sp7 transcription factor; Transcriptional activator essential for osteoblast differentiation. B [...] (431 aa)
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