STRING 9.05 
  DNMT1 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...] (1632 aa)
(Homo sapiens)
Predicted Functional Partners:
histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (482 aa)
ubiquitin-like with PHD and ring finger domains 1; Putative E3 ubiquitin-protein ligase. May pa [...] (805 aa)
proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delt [...] (261 aa)
DNA (cytosine-5-)-methyltransferase 3 beta; Required for genome wide de novo methylation and is [...] (853 aa)
retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Ac [...] (928 aa)
ubiquitin specific peptidase 7 (herpes virus-associated); Cleaves ubiquitin fusion protein subs [...] (1102 aa)
suppressor of variegation 3-9 homolog 1 (Drosophila); Histone methyltransferase that specifical [...] (412 aa)
DNA methyltransferase 1 associated protein 1; Involved in transcription repression and activati [...] (467 aa)
CHK1 checkpoint homolog (S. pombe); Required for checkpoint mediated cell cycle arrest in respo [...] (476 aa)
methyl CpG binding protein 2 (Rett syndrome); Chromosomal protein that binds to methylated DNA. [...] (498 aa)
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Co-expression Experiments Databases Textmining
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