STRING 9.05 
  PTPN22 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid); Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases (807 aa)
(Homo sapiens)
Predicted Functional Partners:
LCK
lymphocyte-specific protein tyrosine kinase; Tyrosine kinase that plays an essential role for t [...] (509 aa)
     0.955
CSK
c-src tyrosine kinase; Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative r [...] (450 aa)
      0.950
SKAP2
src kinase associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion proce [...] (359 aa)
       0.801
PADI4
peptidyl arginine deiminase, type IV; Catalyzes the citrullination/deimination of arginine resi [...] (663 aa)
       0.752
CTLA4
cytotoxic T-lymphocyte-associated protein 4; Possibly involved in T-cell activation. Binds to B [...] (223 aa)
       0.752
ENSG00000230463
HLA class II histocompatibility antigen, DR beta 3 chain Precursor (266 aa)
       0.750
ENSG00000229074
HLA class II histocompatibility antigen, DRB1-7 beta chain Precursor (MHC class I antigen DRB1* [...] (299 aa)
       0.750
DQB1-02
HLA class II histocompatibility antigen, DQ(1) beta chain Precursor (DC-3 beta chain) (281 aa)
       0.750
HLA-DR3B
HLA class II histocompatibility antigen, DR beta 3 chain Precursor (266 aa)
       0.750
ENSG00000206302
HLA class II histocompatibility antigen, DQ(1) beta chain Precursor (DC-3 beta chain) (261 aa)
       0.679
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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